Paola/Bacterion (Salamander '88)

Formerly a supporting protagonist of the second episode of Salamander, which is actually the first one in 'anime' chronology, until her shocking, yet terrifying revelation that she's actually something else... a supreme leader of Bacterion herself!! Humankind's greatest enemy, though she was only an innocent young women from the start, as Paola/Bacterion was the one who orchestrate few disasters in the history of entire galaxy: the first (which was actually a second episode) to unleash the Zelos Force, and third (currently the last one) was to kidnap Stephanie McBain to be fed by her strongest lackey, Gofer. Be careful, freaks, she maybe lovely and enticing at the outside, but she was more than a cruel killer instinct on the inside. She's quite impervious to be a trickster when it comes to a human side anyway. (Well because it's only anime-exclusive, the Gradius main universe was actually a male)